Investigation of in Vitro and in Vivo Metabolism of Schisandrin B from Schisandrae Fructus by Liquid Chromatography Coupled Electrospray Ionization Tandem Mass Spectrometry

Qian, Tianxiu and Leong, Pou Kuan and Ko, Kam Ming and Chan, Wan (2015) Investigation of in Vitro and in Vivo Metabolism of Schisandrin B from Schisandrae Fructus by Liquid Chromatography Coupled Electrospray Ionization Tandem Mass Spectrometry. Pharmacology & Pharmacy, 06 (08). pp. 363-373. ISSN 2157-9423

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Abstract

Schisandrin B (Sch B) is one of the active dibenzocyclooctadiene lignans found in the Schisandrae Fructus. Experimental studies have shown that Sch B possesses various pharmacological properties, including anti-cancer, neuroprotective and nephroprotective activities. However, no detailed information on its biotransformation was reported in the literature. Here, we investigated the in vitro and in vivo metabolism of Sch B by using ultra-performance liquid chromatography coupled with tandem mass spectrometry. In vitro study detected and identified one oxygenated metabolite. Four metabolites were detected and identified from the in vivo study. The results indicated that the metabolism of Sch B mainly involved the demethylation of methoxy groups, the opening of five-member ring and the glucuronidation of metabolites in rats. The metabolites were identified for the first time by MS/MS analyses.

Item Type: Article
Subjects: Academic Digital Library > Chemical Science
Depositing User: Unnamed user with email info@academicdigitallibrary.org
Date Deposited: 23 Feb 2023 09:32
Last Modified: 26 Jul 2024 06:27
URI: http://publications.article4sub.com/id/eprint/713

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