LncRNA-Disease Association Prediction Using Two-Side Sparse Self-Representation

Ou-Yang, Le and Huang, Jiang and Zhang, Xiao-Fei and Li, Yan-Ran and Sun, Yiwen and He, Shan and Zhu, Zexuan (2019) LncRNA-Disease Association Prediction Using Two-Side Sparse Self-Representation. Frontiers in Genetics, 10. ISSN 1664-8021

[thumbnail of pubmed-zip/versions/1/package-entries/fgene-10-00476/fgene-10-00476.pdf] Text
pubmed-zip/versions/1/package-entries/fgene-10-00476/fgene-10-00476.pdf - Published Version

Download (2MB)

Abstract

Evidences increasingly indicate the involvement of long non-coding RNAs (lncRNAs) in various biological processes. As the mutations and abnormalities of lncRNAs are closely related to the progression of complex diseases, the identification of lncRNA-disease associations has become an important step toward the understanding and treatment of diseases. Since only a limited number of lncRNA-disease associations have been validated, an increasing number of computational approaches have been developed for predicting potential lncRNA-disease associations. However, how to predict potential associations precisely through computational approaches remains challenging. In this study, we propose a novel two-side sparse self-representation (TSSR) algorithm for lncRNA-disease association prediction. By learning the self-representations of lncRNAs and diseases from known lncRNA-disease associations adaptively, and leveraging the information provided by known lncRNA-disease associations and the intra-associations among lncRNAs and diseases derived from other existing databases, our model could effectively utilize the estimated representations of lncRNAs and diseases to predict potential lncRNA-disease associations. The experiment results on three real data sets demonstrate that our TSSR outperforms other competing methods significantly. Moreover, to further evaluate the effectiveness of TSSR in predicting potential lncRNAs-disease associations, case studies of Melanoma, Glioblastoma, and Glioma are carried out in this paper. The results demonstrate that TSSR can effectively identify some candidate lncRNAs associated with these three diseases.

Item Type: Article
Subjects: Academic Digital Library > Medical Science
Depositing User: Unnamed user with email info@academicdigitallibrary.org
Date Deposited: 06 Feb 2023 06:04
Last Modified: 26 Jul 2024 06:27
URI: http://publications.article4sub.com/id/eprint/589

Actions (login required)

View Item
View Item