Bias in the arrival of variation can dominate over natural selection in Richard Dawkins’s biomorphs

Martin, Nora S. and Camargo, Chico Q. and Louis, Ard A. and Robinson-Rechavi, Marc (2024) Bias in the arrival of variation can dominate over natural selection in Richard Dawkins’s biomorphs. PLOS Computational Biology, 20 (3). e1011893. ISSN 1553-7358

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Abstract

Biomorphs, Richard Dawkins’s iconic model of morphological evolution, are traditionally used to demonstrate the power of natural selection to generate biological order from random mutations. Here we show that biomorphs can also be used to illustrate how developmental bias shapes adaptive evolutionary outcomes. In particular, we find that biomorphs exhibit phenotype bias, a type of developmental bias where certain phenotypes can be many orders of magnitude more likely than others to appear through random mutations. Moreover, this bias exhibits a strong preference for simpler phenotypes with low descriptional complexity. Such bias towards simplicity is formalised by an information-theoretic principle that can be intuitively understood from a picture of evolution randomly searching in the space of algorithms. By using population genetics simulations, we demonstrate how moderately adaptive phenotypic variation that appears more frequently upon random mutations can fix at the expense of more highly adaptive biomorph phenotypes that are less frequent. This result, as well as many other patterns found in the structure of variation for the biomorphs, such as high mutational robustness and a positive correlation between phenotype evolvability and robustness, closely resemble findings in molecular genotype-phenotype maps. Many of these patterns can be explained with an analytic model based on constrained and unconstrained sections of the genome. We postulate that the phenotype bias towards simplicity and other patterns biomorphs share with molecular genotype-phenotype maps may hold more widely for developmental systems.

Item Type: Article
Subjects: Academic Digital Library > Biological Science
Depositing User: Unnamed user with email info@academicdigitallibrary.org
Date Deposited: 09 Apr 2024 12:53
Last Modified: 09 Apr 2024 12:53
URI: http://publications.article4sub.com/id/eprint/3253

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