DcoD Ameliorate Diabetic Retinopathy through Aldose-Sorbitol Cleavage

A new effect of D-Co-D tablets, polyherbal Siddha drug for the management of diabetes mellitus has been discovered in the present study relating to its effect in reducing the episode of sugar cataract a common ocular problem encountered among diabetic people. D-Co-D found to exert biphasic action on both aldose reductase and sorbitol dehydrogenase. Aldose reductase expression increase over 30% in diabetic condition to convert excess glucose to sorbitol which is further cleaved into fructose by another enzyme sorbitol dehydrogenase; D-co-D inhibited the activity of both enzymes comparable to the known positive control. The herbs in the formulation suh as Tinospora cordifolia was effective on aldose reductase while Momordica charantia and Zingiber officinale where effective on sorbitol dehydrogenase. Result of the findings and the treatment advancement of D-Co-D is discussed in the article.