An Overview of Penicillin: The Old/New Wonder Drug

Penicillin (PCN) has been shown to treat psoriasis effectively and be curative in many cases.
Streptococcus is the organism responsible for beginning the process and has previously escaped
detection by moving intracellularly or by forming biofilms. The treatment is low dose for many months
and thus is similar to rheumatic fever. Arthritis has been shown to be caused by biofilm-forming dental
and Lyme spirochetes, and these organisms, like the streptococcus in psoriasis, have escaped
detection. Penicillin, plus a biofilm-dispersing agent is effective in treating arthritis in which tissue
destruction has not already occurred. Alzheimer’s disease has been shown to be caused by those
same spirochetes involved in arthritis, and, is in every way, similar to the dementia of neurosyphilis
caused by Treponema pallidum. These organisms make biofilms that induce B amyloid and a Toll-like
receptor 2 response leading to tissue destruction. Penicillin given prior to the organisms’ arrival in the
brain (or before they create biofilms) would effectively prevent dementia in Alzheimer’s as it does in
syphilis.
We have shown that biofilm-forming staphylococci are integral to the etiology of atopic dermatitis.
Along with standard corticosteroid therapy, antibacterial treatment, as opposed to antibiotics, appears
to be a better treatment in AD because all the organisms are multi-drug resistant and 60% are MRSA
or MSRE. Treatment with PCN in psoriasis, arthritis, and syphilis, has thus far not led to resistance
and may actually prevent resistance by killing organisms before they make biofilms and share
resistance genes. Due to its efficacy and affordability, much effort needs to be put into investigation
on the therapeutic role of penicillin in psoriasis, arthritides (including rheumatoid arthritis and
osteoarthritis), Lyme disease and Alzheimer’s disease. The association of streptococci and
spirochetes with the corresponding diseases like psoriasis, Lyme disease, arthritides, and Alzheimer’s
disease suggests treatment with penicillin can be just as miraculous as when it was first introduced.