Emphasizing the Impact of Biofilms in Alzheimer’s Disease Compared to Other Diseases in Which They Play a Role

Herein we present the findings related to biofilms in Alzheimer’s disease and compare them to known
findings related to biofilms in other chronic diseases. Similarities include microbes making the biofilms
both intra and extracellularly, the interaction of the innate immune system in many instances, the
devastating impact of the adaptive immune system, and the devastating impact resulting from the
various genes involved. Differences include location, the production of beta amyloid, neurofibrillary
tangles, and hyperphosphorylated tau protein. The diseases compared include atopic dermatitis,
psoriasis, tinea versicolor, leprosy, gout, rheumatoid arthritis and other arthritides. It is obvious that
Alzheimer’s disease differs from the other chronic diseases in the production of Abeta, p-tau, and
neurofibrillary tangles. It does not differ with regard to the adaptive immune system creating more
destruction than the innate (cf stroke), and it does not differ in regard to the impact of a gene (cf AD 7)
also creating destruction.