Synthesis of Analogues of Dicoumarol and Their Biological Evaluation

Obi, Julie and Ezenwa, Tagbo (2018) Synthesis of Analogues of Dicoumarol and Their Biological Evaluation. International Journal of Chemistry, 10 (3). p. 1. ISSN 1916-9698

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Abstract

Both symmetrical (1a-f) and asymmetrical (2a-f) analogues of dicoumarol were synthesized in 20 – 86% yield by using microwave assisted one-pot protocol. Their ability to inhibit NAD (P)H:oxidorectase quinone 1 (NQO1) and cytotoxicity towards A549 small lung cancer cell line were evaluated. Interestingly, (E)-3-(2-hydroxynaphthalen-1-y)chroman-2,4-dione (2d) showed not only moderate inhibitory potency (IC50 = 20 ± 6 nM) towards NQO1 but also was toxic (IC50 = 9.2 ± 0.2 µM) towards the A549 small lung cancer cell line.

Item Type: Article
Subjects: Academic Digital Library > Chemical Science
Depositing User: Unnamed user with email info@academicdigitallibrary.org
Date Deposited: 20 Apr 2023 06:24
Last Modified: 19 Mar 2024 04:00
URI: http://publications.article4sub.com/id/eprint/1291

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